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| Oligosaccharides in Protein Folding |
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Fifty percent of cellular proteins are glycoproteins, and their carbohydrate components serve many
crucial roles, including enabling or stabilizing the protein's folding. Carbohydrates are transferred
to nascent proteins in the endoplasmic reticulum by polypeptide glycosyltransferases. Glycosylation
then plays a role in the further processing of the nascent protein.
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| Calnexin and Calreticulin |
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Calnexin and calreticulin are chaperones binding nacent proteins in the endoplasmic reticulum, the former as a
transmembrane protein, the latter in the lumen. Both chaperones bind sites of
N-glycosylation on nascent proteins, with identical specificity.
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| Saccharomyces cerevisiae |
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