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monosaccharides glycans transferases oligosaccharides protein-carbohydrate interactions
 Glycans

 - Overview
 - N-Linked
 - Protein Folding
 - O-Linked
   · Blood Group Determinants
 - Glycosaminoglycans
 - Glycosphingolipids
 - GPI Anchors
 - O-GlcNAc


Reference:
Essentials of Glycobiology
by Varki et al.
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>> N-linked

diagram adapted from: Bill, et. al., Protein Glycosylation (148)


N-glycans attach to Aspargine residues of nascent proteins at sites conforming to the pattern Asn-X-(Ser/Thr). Synthesis of the core precursor begins in the cytoplasm, the core oligosaccharide structure is flipped into the lumen of the ER and further glycosylated. The core structure is transferred in the Rough ER to a nascent protein by an OST (oligosaccharyltransferase) and further processed. Diversification then occurs in the Golgi resulting in various antennary structures.



Site designed and maintained by Aidan Ryan, LECB Structural Glycobiology Section, NCI Frederick, Maryland