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Protein-Carbohydrate Interactions

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 - Lactose Synthase
     · Enzyme Kinetics


Reference:
Conformation of Carbohydrates
by V.S.R. Rao, P.K. Qasba, P.V. Balaji and R. Chandrasekaran
Conformation of Carbohydrates




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>> Enzyme Kinetics for Gal-T1
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Catalytic Action of Gal-T1
Reaction Catalysation. In the presence of a-Lactalbumin, metal ions, sugar substrate, and Glucose, Gal-T1 transfers Galactose to Glucose, synthesizing Lactose. In the absence of a-Lactalbumin, Gal-T1 transfers Galactose to GlcNac, synthesizing Gal-(b1-4)-GlcNAc (N-acetyl Lactoseamine). The acceptor sugar, GlcNAc or Glucose, binds in the acceptor binding pocket of Gal-T1.

B. Ramakrishnan and Pradman K. Qasba: J.Mol. Biol. 2001, v310, p.205-218 		The 1:1 complex of a-Lactalbumin with Gal-T1 forming Lactose Synthase.



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