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Glycoconjugates and glycans are assembled by glycoslytransferases in reactions specific to the sugar donor and acceptor.
These enzymes generally reside in the golgi compartament, with their catalytic domain facing the lumen.
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All GTs transfer from a sugar nucleotide to an acceptor, most often a sugar, or to a hydroxy group of a serine or
theronine residue (as in the case of O-GalNAc transferases). The sugar may be a di- or mono-nucleotide (as in
CMP-Sia).
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